Characterization of the ars gene cluster from extremely arsenic-resistant Microbacterium sp. strain A33.

نویسندگان

  • Asma Achour-Rokbani
  • Audrey Cordi
  • Pascal Poupin
  • Pascale Bauda
  • Patrick Billard
چکیده

The arsenic resistance gene cluster of Microbacterium sp. A33 contains a novel pair of genes (arsTX) encoding a thioredoxin system that are cotranscribed with an unusual arsRC2 fusion gene, ACR3, and arsC1 in an operon divergent from arsC3. The whole ars gene cluster is required to complement an Escherichia coli ars mutant. ArsRC2 negatively regulates the expression of the pentacistronic operon. ArsC1 and ArsC3 are related to thioredoxin-dependent arsenate reductases; however, ArsC3 lacks the two distal catalytic cysteine residues of this class of enzymes.

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عنوان ژورنال:
  • Applied and environmental microbiology

دوره 76 3  شماره 

صفحات  -

تاریخ انتشار 2010